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Research Overview
Long R3 analogue of IGF-1 with reduced IGF-binding protein affinity, giving longer systemic half-life. Activates IGF-1R and downstream PI3K/Akt/mTOR and Ras/MAPK pathways to stimulate cell growth, proliferation, and protein synthesis.
Overview
IGF-1 LR3 is a modified form of IGF-1 in which an N-terminal extension and a single amino acid substitution dramatically reduce binding to the six IGF-binding proteins that normally regulate IGF-1 availability in biological systems. This reduced IGFBP binding results in a higher proportion of unbound, biologically active compound and an extended half-life compared to native IGF-1, making LR3 a useful research tool for studying IGF receptor signalling without the confounding effects of IGFBP-mediated sequestration.
In preclinical cell biology research, IGF-1 LR3 has been extensively used to study IGF-1 receptor (IGF-1R) signalling through the PI3K-Akt-mTOR and Ras-ERK pathways, which mediate cell survival, proliferation, and protein synthesis. Its extended activity window compared to native IGF-1 has made it a preferred research tool in cell culture systems where sustained IGF-1R stimulation is required for experimental paradigms.
Compliance
Sold strictly as a research chemical for non-human, in-vitro, and laboratory use
FDA approved compound
Listed as prohibited under WADA anti-doping regulations
Prescription availability in Australia and internationally
In Australia, igf-1 lr3 (long arginine 3 igf-1) has no TGA approval for therapeutic use. It is sold by Capital Peptides strictly as a research chemical for non-human, in-vitro, and laboratory research use only.
Pharmacology
Long R3 analogue of IGF-1 with reduced IGF-binding protein affinity, giving longer systemic half-life. Activates IGF-1R and downstream PI3K/Akt/mTOR and Ras/MAPK pathways to stimulate cell growth, proliferation, and protein synthesis.
Support
Available from Capital Peptides
For research use only. Capital Peptides products are not approved by the TGA for therapeutic use. By purchasing you confirm you are a licensed research entity or qualified professional.